细履平沙 发表于 2007-10-17 11:14:31

红霉素

红霉素:
产生菌:Streptomyces erythreus
结构:Erythromycin is a polyhydroxylactone that contains two sugars. The aglycone portion of the molecule, erythranolide, is a 14-membered lactone ring. An amino sugar, D-desosamine, is attached through a b-glycosidic linkage to the C-5 position of the lactone ring. The tertiary amine of desosamine confers a basic character to erythromycin (pK 8.8). Through this group, a number of acid salts of the antibiotic have been prepared. A second sugar, L-cladinose, which is unique to erythromycin, is attached via a b-glycosidic linkage to the C-3 position of the lactone ring. The fermentation process that produces commercial grade erythromycin is not entirely selective. It results in the production of small quantities of erythromycin B (EB), C(EC), D(ED), E(EE) and F(EF), in addition to EA, which is the major component.EB, EC and EE are the most important impurities found in commercial samples of erythromycin.

小春 发表于 2009-9-30 10:19:32

楼主是做红霉素发酵的吗?不知道你是用的什么菌?我很想知道在发酵过程中前期、中期、后期的菌丝形态的差异,不知道能传几张图片来看看不?

fwtems 发表于 2014-1-10 12:38:33

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