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[综合] 两个概念,对于临床试验非常关键

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发表于 2016-8-11 08:58:45 | 显示全部楼层 |阅读模式
Sensitivity (also called the true positive rate, or the recall in some fields) measures the proportion of positives that are correctly identified as such (e.g., the percentage of sick people who are correctly identified as having the condition).
Specificity (also called the true negative rate) measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people who are correctly identified as not having the condition).
A worked exampleA diagnostic test with sensitivity 67% and specificity 91% is applied to 2030 people to look for a disorder with a population prevalence of 1.48%
Patients with bowel cancer
(as confirmed on endoscopy)
Condition positiveCondition negative
Fecal
occult
blood

screen
test
outcome
Test
outcome
positive
True positive
(TP) = 20
False positive
(FP) = 180
Positive predictive value
= TP / (TP + FP)
= 20 / (20 + 180)
= 10%
Test
outcome
negative
False negative
(FN) = 10
True negative
(TN) = 1820
Negative predictive value
= TN / (FN + TN)
= 1820 / (10 + 1820)
99.5%
Sensitivity
= TP / (TP + FN)
= 20 / (20 + 10)
67%
Specificity
= TN / (FP + TN)
= 1820 / (180 + 1820)
= 91%

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